最新应用笔记

Spatially resolved gene expression can provide a powerful complement to traditional histopathology methods, enabling a greater understanding of cellular heterogeneity and organization within the central nervous system.

In order to develop novel therapeutic treatments, it is key to understand the tissue-specific steroids metabolic pathways. Mass Spectrometry Imaging (MSI) is a powerful tool to visualize the distribution of such molecules involved in tissue metabolism.

Research scientists are all too familiar with the catastrophic effects of equipment failure. During October 2020, a pharmaceutical lab associate lost several months’ worth of work due to three incubators losing humidity control resulting in the loss of valuable cell lines.

Complex 3D biological models such as organoids and patient-derived spheroids are gaining popularity in many biomedical research areas because they more closely recapitulate in vivo tissues.

Rapid characterization of protein therapeutic charge variants can be challenging for the growing number and wider variety of new modality drug candidates. Automated capillary electrophoresis instruments offer fast separation times and high reproducibility for capillary isoelectric focusing.

An AAV is a non-enveloped virus with a lack of pathogenicity, low immunogenicity, broad tropism and persistent transgene expression in both proliferating and quiescent cells. This makes AAVs an attractive choice for creating viral vectors for gene therapy for a variety of diseases.

The purity of adeno-associated virus (AAV) capsid proteins has important implications for efficacy of the viral vector. A robust analytical method for assessment of the capsid purity for a range of serotypes that can provide reliable results in a timely fashion is desirable.

Automated capillary electrophoresis instruments offer fast separation times and proven, high reproducibility for capillary sodium dodecyl sulfate gel electrophoresis (SDS-CGE), thus representing an excellent tool for the analysis of therapeutic proteins.

Download this free application focus to learn more about innovative next-generation methylation detection systems.

Download this app note to discover methylation capture panels that show excellent performance across a wide range of methylation targets, enable highly optimized designs out of the box and are compatible with enzymatic or bisulfite conversion.